2019

Using Ubiquitin Binders to Decipher the Ubiquitin Code. Mattern M; Sutherland J; Kadimisetty K; Barrio R; Rodriguez M. Trends in Biochemical Sciences. 2019 Feb 25. doi: 10.1016/j.tibs.2019.01.011

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia. Qi Jin, Q, Martinez, C, Arcipowski, K, Zhu, Y, Gutiérrez-Díaz, B, Wang, K, Johnson, M, Volk, A, Wang, F, Wu, J, Grove, C, Wang, H, Sokirniy, I, Thomas, P, Goo, Y, Abshiru, N, Hijiya, N, Peirs, S, Vandamme, N,  Berx, G, Goossens, S, Marshall, S, Rendleman, E, Takahashi, Y, Wang, L, Rawat, R, Bartom, E,  Collings, C, Van Vlierberghe, P, Bourquin, J-P, Bornhauser, B, Serafin, V, Bresolin, S, Paganin, M, Accordi, B, Basso, G,. Kelleher, N, Weinstock, J, Kumar, S, Crispino, J, Shilatifard, A, Strikoudis, A, Mantis, C, Kandela, I, Kelly, S, Ueberheide, B, and Ntziachristos, P. Clinical Cancer Research- an official journal of the American Association for Cancer Research. 2019 Jan 1;25(1):222-239. doi: 10.1158/1078-0432.CCR-18-1740

2018

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. Gennaro, V J; Stanek, T J; Peck, A R; Sun, Y; Rui, H; Wang, F; Butt T; Qie, S; Diehl, J A; McMahon, S B. Proceedings of the National Academy of Sciences of the United States of America. 2018 Sep 7;115(40):e9298-e9307. https://doi.org/10.1073/pnas.1807704115

2017

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744.

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.  Lv, K , Jiang, J,  Donaghy, R, Riling, C., Cheng, Y, Chandra, V, Rozenova, K, An, W, Mohapatra, B, Goetz, B, Pillai, V, Han, X, Todd, E, Jeschke, G, Langdon, W, Kumar, S, Hexner, E, Band, H, and Tong, W. Genes & Development (2017), 31(10), 1007-1023.

Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from a-Santonin DerivativesChen, H, Wu, G, Gao, S, Guo, R, Zhao, Z, Yuan, H, Liu, S, Wu, J, Lu, X, Yuan, X, Yu, Z, Zu, X, Xie, X, Yang, N, Hu, Z, Sun, Q, and Zhang, W.  Journal of Medicinal Chemistry (2017), 60(16), 6828-6852.

USP7-Specific Inhibitors Target and Modify the Enzyme’s Active Site via Distinct Chemical Mechanisms.  Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5. doi: 10.1016/j.chembiol.2017.09.004.

Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. Wu, J., Kumar, S., Wang, F., Wang, H., Chen, L., Arsenault, P., Mattern, and, M., and Weinstock, J.J. Med. Chem. 2017, DOI: 1021/acs.jmedchem.7600498.

2016

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastomaTavana, O., Li, D., Dai, C., Lopez, G., Banerjee, D., Kon, N., Chen, C., Califano, A., Yamashiro, D., Sun, H., and Gu, W. Nature Med 2016, Oct; 22(10):1180-1186.

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. Wang, L., Kumar, S., Dahiya, S., Wang, F., Wu, J., Newick, K., Han, R., Samanta, A., Beier, U.H., Akimova, T., Bhatti, T.R., Nicholson, B., Kodrasov, M.P., Agarwal, S., Sterner, D.E., Gu, W., Weinstock, J., Butt, T.R,, Albelda, S.M., Hancock, W.W. EBioMedicine 2016, Nov; 13: 99-112.

2015

Itch WW domains inhibit its E3 ubiquitin ligase activity by blocking E2-E3 transthiolation.
Riling, C., Kamadurai, H., Kumar, S., O’Leary, C.E., Wu, K.P., Manion, E.E., Ying, M., Schulman, B.A., and Oliver, P.M. J. Biol. Chem. 2015, August 5. (Epub ahead of print).

2014

Proteasome inhibitors vs. E3 ligase inhibitors for cancer therapy.
Mattern, M.R., Eddins, M.J., Agarwal, S., Sterner, D.E., Kodrasov, M.P., Suresh Kumar, K.G., Wu, J., and Nicholson, B. In: QP Dou, Ed., Resistance to proteasome inhibitors in cancer. New York, NY: Springer Publishing Co. 2014, August. 291-316.

Discovery of therapeutic deubiquitylase effector molecules: current perspectives. 
Nicholson, B., Suresh Kumar, K.G., Agarwal, S., Eddins, M., Marblestone, J.G., Wu, J., Kodrasov, M.P., LaRocque, J.P., Sterner, D.E., and Mattern, M.R. J. Biomol. Screening. 2014, March.19(7):989-999 (Epub ahead of print).

2013

Comprehensive Ubiquitin E2 Profiling of Ten Ubiquitin E3 Ligases.
Marblestone J.G., Butt S., McKelvey D.M., Sterner D.E., Mattern M.R., Nicholson B., Eddins M.J.  Cell Biochem Biophys. 2013 Sep;67(1):161-7.

Spongiacidin C, a pyrrole alkaloid from the marine spongeStylissa massa, functions as a USP7 inhibitor.
Yamaguchi, M., Miyazaki, M., Kodrasov, M.P., Rotinsulu, H., Losung, F., Mangindaan, R.E.P., de Voogd, N.J., Yokosawa, H., Nicholson, B., and Tsukamoto, S. Bioorganic & Medicinal Chemistry Letters. 2013 May 3. 23; 3884-3886.

2012

Bioluminescence Assay Platform for Selective and Sensitive Detection of Ub/Ubl Proteases.
Orcutt, S.J., Wu, J., Eddins, M.J., Leach, C.A., and Strickler, J.E. Biochim Biophys Acta. 2012 November; 1823(11): 2079-2086.

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance.
Chauhan, D., Tian, Z., Nicholson, B., Kumar, K.G., Zhou, B., Carrasco, R., McDermott, J.L., Leach, C.A., Fulcinniti, M., Kodrasov, M.P., Weinstock, J., Kingsbury, W.D., Hideshima, T., Shah, P.K., Minvielle, S., Altun, M., Kessler, B.M., Orlowski, R., Richardson, P., Munshi, N., and Anderson, K.C. Cancer Cell. 2012 Sep 11;22(3):345-58.

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Weinstock, J., Wu, J., Cao, P., Kingsbury, W.D., McDermott, J.L., Kodrasov, M.P., McKelvey, D.M., Suresh Kumar, K.G., Goldenberg S.J., Mattern, M.R., and Nicholson, B. ACS Medicinal Chemistry Letters. 2012 Sep. 3(10);789–792.

Analysis of ubiquitin E3 ligase activity using selective polyubiquitinbinding proteins
.

Marblestone, J.G., LaRocque J.P., Mattern, M.R., and Leach, C.A., Biochimica et Biophysica Acta. 2012 June 18. 1823; 2094-2097.

Ubiquitin-based anticancer therapy: Carpet bombing with proteasome inhibitors vs surgical strikes with E1, E2, E3, or DUB inhibitors.
Mattern, M.R., Wu, J., and Nicholson, B. Biochimica et Biophysica Acta. 2012 May 17; 1823. 2014-2021

2011

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes.
Altun, M., Kramer, H.B., Willems, L.I., McDermott, J.L., Leach, C.A., Goldenberg, S.J., Kumar, K.G.S., Konietzny, R., Fischer, R.,  Kogan, E., Mackeen, M.M.,  McGouran, J., Khoronenkova, S.V.,  Parsons, J.L., Dianov, G.L., Nicholson, B.,Kessler, B.M. Chemistry & Biology, 2011 Nov 23;18(11):1401-12

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.
Edelmann, M.J., Nicholson, B., Kessler, B.M., Expert Review Mol Med. 2011 Nov 17;13:e35.

Tissue-specific expression and post-translational modifications of plant- and bacterial-type phosphoenolpyruvate carboxylase isozymes of the castor oil plant, Ricinus communis L.
O’Leary, B., Fedosejevs, E.T., Hill, A.T., Bettridge, J., Park, J., Rao, S.K., Leach, C.A., Plaxton, W.C. J Exp Bot. 2011 Nov;62(15):5485-95

A baker’s dozen of ubiquitin. 
Haas, A.L., Leach, C.A. Cell Biochem Biophys. 2011 Jun;60(1-2):1

The Multifaceted Roles of USP7: New Therapeutic Opportunities.
Nicholson, B., and Suresh Kumar, K.G., Cell Biochem Biophys. 2011 Jun;60(1-2):61-8.

Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy. 
Eddins, M.J., Marblestone, J.G., Suresh Kumar, K.G., Leach, C.A., Sterner, D.E., Mattern, M.R., and Nicholson, B. Cell Biochem Biophys. 2011 Jun;60(1-2):113-8.

The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/β-catenin signaling. 
Lui, T.T., Lacroix, C., Ahmed, S.M., Goldenberg, S.J., Leach, C.A., Daulat, A.M., Angers, S. Mol. Cell Biol. 2011 May;31(10):2053-65.

Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.
Tian, X., Isamiddinova, N.S., Peroutka, R.J., Goldenberg, S.J., Mattern, M.R., Nicholson, B., Leach, C..Assay Drug Dev Technol. 2011 Apr;9(2):165-73.

2010

Novel Approach for Characterizing Ubiquitin E3 Ligase Function.
Marblestone, J.G., Suresh Kumar, K.G., Eddins, M.J., Leach, C.A., Sterner, D.E., Mattern, M.R., and Nicholson, B. (2010). J Biomol Screening. Dec;15(10):1220-8

Ubiquitin Drug Discovery and Diagnostics 2009 – First Annual Conference.
Marblestone, J,G,. (2010). IDrugs, (12): 750-753

Strategies for the Identification of Ubiquitin Ligase Inhibitors.
Goldenberg, S.J., Marblestone, J.G., Mattern, M.R. and Nicholson, B. (2010). Biochemical Society Transactions, 38: 132-6