R&D, Medicinal Chemistry

Scientist/Senior Scientist, Medicinal Chemistry

Progenra has developed a unique assay platform and compound profiling capability to identify selective inhibitors that target ubiquitin pathway enzymes. We are currently seeking candidates for the position of Scientist as well as Senior Scientist in Medicinal Chemistry.


Description:   As a medicinal chemist you will apply state of the art synthetic chemistry, structural and computational approaches to discover and synthesize novel medicines for a variety of diseases including cancer, inflammation, and neurodegenerative diseases.The Research Scientist will independently plan and implement efficient synthetic routes for target compounds and apply state of the art purification and characterization techniques, conduct research with the drug discovery team to develop SAR, analyze the data, and write laboratory reports. The position provides opportunities to grow, write papers and patents, and present data at internal, national and international meetings.


Qualifications/Requirements: BS/ MS/ Ph.D. in organic/medicinal chemistry with 0-10 years’ experience working in a medicinal chemistry laboratory setting with expertise in lead optimization and SAR evolution. Strong synthetic organic chemistry background is required with experience in applicable analytical chemistry/purification chemistry techniques (NMR, HPLC, LC-MS). Experience with a broad range of synthetic transformations for project execution and excellent verbal and written communication and skills for effective drug discovery team participation are required.  Experience with molecular modeling and structure-based drug design is a plus. Established track record of working well in a team setting and a demonstrated understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement (publications, presentations, patents, etc.) are desired.  Demonstration of advanced level of understanding of project goals and methods for senior candidates is also desired. Knowledge of the ubiquitin-proteasome pathway is a plus.


Other attributes: You will work in a highly entrepreneurial environment. The ability to adapt quickly to change and manage multiple priorities is essential, as are interpersonal skills and the ability to work as a member of a team.


Benefits: Our employees enjoy a highly competitive compensation package, including excellent salaries based on qualifications and experience, and benefits including:

  • Medical, dental, and vision coverage
  • Tax-effective reimbursement accounts for childcare and medical expenses
  • 10 days annual vacation, 10 paid holidays each year, 5 paid sick days per year
  • Retirement Savings Plan with a company match that vests immediately
  • Bonus and Life Insurance programs

Qualified applicants should submit a cover letter and resume to careers@progenra.com