R&D, Medicinal Chemistry

Medicinal Chemist, Scientists, PROTAC Drugs


Position Summary:

Do you like to explore frontiers of medicine to discover breakthrough therapies and first-in-class drugs?  Ubiquitin proteasome system (UPS) and protein targeting chimera (PROTAC) drugs provides a challenge as a new wave of drugs are emerging from this pathway www.progenra.com. Progenra Inc. a biotech company located in suburbs of Philadelphia PA, has open positions. From scientist to senior scientists Medicinal Chemistry. You will apply state of the art Med Chem approaches to synthesize PROTAC molecules towards broad spectrum of diseases, including immune oncology, inflammation, and neurodegeneration such as Alzheimer’s and Parkinson’s diseases. Progenra has developed a unique E3 ubiquitin ligase platform for novel PROTAC drugs.

Requirements and Responsibilities: Ph.D. in Organic Chemistry or Medicinal Chemistry

    • A dynamic medicinal chemist, that drives medicinal chemistry functions for drug discovery projects, working in concert with molecular and cellular biology, pharmacology, ADME, structural biology, and other key functions
    • Participate in screening strategies, perform literature reviews, design, propose, and execute medicinal chemistry plans in house and outside CROs
    • Participate in portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement
    • Participate in implementing strategies that support medicinal chemistry growth objectives at Progenra
    • Serve as a scientific expert in medicinal chemistry with both internal and external partners
    • Maintain a significant level of productivity in the laboratory setting
    • Write scholarly papers, patents and provide intellectual leadership for the company


    • 0-10+ years of laboratory experience in an academic, industrial or drug discovery setting
    • BS and or Ph.D in Medicinal Chemistry or related synthetic organic chemistry
    • Broad and proven experience in one or more therapeutic area in medicinal chemistry
    • Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to conduct medicinal chemistry successfully and simultaneously on multiple projects is beneficial
    • Knowledge of and/or experience with computational chemistry methods and biophysical techniques
    • Strong problem-solving skills for developing creative, innovative solutions, and project management
    • Track record of scientific contributions including peer reviewed publications and patent writings
    • Record of maintaining a strong lab presence and commitment to invest up to 80% of time in the lab
    • Knowledge of UPS enzymes PROTAC is beneficial


Progenra employees receive an outstanding total compensation package, including competitive salaries based on qualifications and experience, and benefits including:

    • Medical, dental, and vision coverage
    • Tax-effective reimbursement accounts for childcare and medical expenses
    • 10 days annual vacation, 10 paid holidays each year, 5 paid sick days per year
    • Retirement Savings Plan with a company match that vest in three months
    • Bonus and Life Insurance programs
    • Relocation Assistance


Applications can be submitted online at careers@progenra.com.