R&D, Biology

Director Drug Discovery, PROTAC Drugs

Position Summary:

Do you like to explore frontiers of biology to discover breakthrough therapies and first-in-class drugs?  Ubiquitin proteasome system (UPS) and protein targeting chimera (PROTAC) drugs provides a challenge as a new wave of drugs are emerging from this pathway www.progenra.com. Progenra Inc. a biotech company located in suburbs of Philadelphia PA, has open positions. Director of drug discovery to Senior Scientists are expected to translate the cellular mechanisms of enzymes that act on ubiquitin into novel and efficacious therapies for a broad spectrum of diseases including immune oncology, inflammation, and neurodegeneration such as Alzheimer’s and Parkinson’s diseases. Knowledge in cell and molecular biology, expertise in assay development, biophysical evaluation of proteins is an advantage. The senior scientist occupies a leadership position on a team to develop drug discovery technologies. He/she will write scientific articles and patents, and present data at national and international meetings.

Requirements: Ph.D. in a Life Sciences, Biochemistry, Molecular Biology, Cell Biology or Pharmacology

  • 0-10+ years of laboratory experience in an academic, industrial or drug discovery setting
  • Experience in biochemistry, structural biology, cell and or molecular biology is required
  • Knowledge of the UPS is desirable but not essential
  • Experience in the field of cell signal transduction
  • Write scholarly papers, patents and provide intellectual leadership for the company
  • Demonstrated record of achievement through publications in high profile journals
  • Communication, troubleshooting, and organizational skills
  • Experience in assay development and high throughput screening is a plus

Duties & Responsibilities:

 Provide day-to-day leadership in R&D that mirrors the Progenra strategic plan

  • Develop innovative technologies to assay UPS enzymes and discover novel drugs
  • Apply expertise in biochemistry, molecular biology, cell biology, or Medicinal chemistry
  • Play major roles in Progenra’s industry and academic collaborations
  • Publish scientific articles and file patent applications, represent Progenra in national conferences


 Progenra employees receive an outstanding total compensation package, including competitive salaries based on qualifications and experience, and benefits including:

  • Medical, dental, and vision coverage
  • Tax-effective reimbursement accounts for child care and medical expenses
  • 10 days annual vacation, 10 paid holidays each year , 5 paid sick days per year
  • Retirement Savings Plan with a company match that vests immediately
  • Bonus and Life Insurance programs
  • Relocation Assistance

Applications can be submitted online at careers@progenra.com.