Protein Misfolding-Neurodegeneration

Abstract- Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in which...

Ubiquitination and Cancer

Abstract- Dynamic modulation and post-translational modification of proteins are tightly controlled biological processes that occur in response to physiological cues. One such dynamic modulation is ubiquitination, which marks proteins for degradation via the...

Hanson Wade’s Targeted Protein Degradation Conference

“Encapsulating the excitement of the field of protein degradation, the 2nd TPD Summit 2019 is the definitive comprehensive and industry-dedicated summit for the field of protein degradation – focused on optimizing target validation, improving medicinal chemistry &...