Mitochondria and Aging
Understanding how cellular powerhouses shape the aging process and related diseases.
Energy Producers with Aging Impact
Mitochondria, the energy-producing organelles within cells, play a central role in the aging process due to their involvement in cellular metabolism, oxidative stress, and regulation of cell death. As organisms age, mitochondrial function tends to decline, leading to reduced energy production and increased generation of reactive oxygen species (ROS), which can damage DNA, proteins, and lipids.
Mitochondrial Dysfunction in Aging
This mitochondrial dysfunction contributes to the gradual deterioration of tissue and organ function commonly seen in aging. Moreover, mutations in mitochondrial DNA accumulate over time, further impairing mitochondrial performance and promoting age-associated diseases such as neurodegeneration, cardiovascular disorders and sarcopenia.
